Application

Research CategorySignaling

This Anti-c-met Antibody, clone 4AT44 is validated for use in WB for the detection of c-met.

Research Sub CategoryGrowth Factors & Receptors

Western Blot: 1:100-1:500.

ELISA (direct): 1:1,000

Optimal working dilutions must be determined by the end user.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Purified recombinant catalytic domain of human Met

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 04-1051

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.

Format: Purified

Specificity

Reacts with c-met/HGFR (Hepatocyte growth factor receptor). The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for c-met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal c-met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.